Skip to main content
. Author manuscript; available in PMC: 2019 Aug 10.
Published in final edited form as: Annu Rev Physiol. 2019 Feb 10;81:505–534. doi: 10.1146/annurev-physiol-020518-114700

Figure 1.

Figure 1

Chronology of vascular normalization in preclinical and clinical studies. This time line shows the key concepts and findings related to vascular and cancer-associated fibroblast/extracellular matrix normalization from the senior author’s laboratory. References for the bottom panels can be found in Reference 4. Abbreviations: AAT, antiangiogenesis therapies; ASI, angiotensin system inhibitor; CRC, colorectal cancer; FDA, Food and Drug Administration; GBM, glioblastoma; HCC, hepatocellular carcinoma; ICB, immune checkpoint blocker; NSCLC, non-small-cell lung cancer; PDAC, pancreatic ductal adenocarcinoma; TME, tumor microenvironment.