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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Anal Chem. 2018 Dec 18;91(1):190–209. doi: 10.1021/acs.analchem.8b05071

Figure 3.

Figure 3

Spectra of C-reactive protein (CRP) pentamer undergoing SID (A and C) and CID (B and D). The top two spectra (A and B) utilize charge-reducing conditions to reduce the average charge state of the precursor ions relative to the spectra in (C and D) under “normal”-charge conditions. Under charge-reducing conditions, a greater variety of subcomplex products are formed via SID indicating that subunit interactions are maintained to greater extent under lowercharge. In both cases, CID results only in the production of monomer and tetramer. Reproduced from Zhou, M.; Dagan, S.; Wysocki, V.H., Impact of Charge State on Gas-Phase Behaviors of Noncovalent Protein Complexes in Collision Induced Dissociation and Surface Induced Dissociation. Analyst 2013, 138, 1353–1362.58 with permission from the Royal Society of Chemistry.