Skip to main content
. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Hypertens Res. 2019 Jan 21;42(7):960–969. doi: 10.1038/s41440-019-0212-z

Fig. 4.

Fig. 4

Metformin improves vascular function independent of hypertension. a Systolic blood pressure (SBP) was similar among groups and in the range of normotensive values. b, c Contractile response to thromboxane analogue (U46619) and phenylephrine (PE) in mesenteric resistance arteries (MRA) was similar among groups. d Endothelial-dependent relaxation to acetylcholine (Ach) was damaged in the MRA of C57/Bl6 mice after intraperitoneal injection of tunicamycin (Tun, 1 mg/kg, two injections/week for 2 weeks) and was significantly improved with metformin treatment (300mg.kg−1 body weight per day). #p < 0.05 vs Sham; *p < 0.05 vs Sham + Tun. e Endothelial-independent relaxation to sodium nitroprusside (SNP) was similar among groups. f Immunoblots for P-eNOS and T-eNOS and quantification of the ratio of P-eNOS/T-eNOS showed decreased eNOS activity in the MRA of C57/Bl6 mice after intraperitoneal injection of tunicamycin (Tun, 1 mg/kg, two injections/week for 2 weeks), which was restored with metformin treatment (300mg.kg−1 body weight per day).*p < 0.05 vs Sham + Tun