Figure 3. CHCHD10S55L mice display cardiac hypertrophy exacerbated in breeding females.
A. Hearts at 330 days of age. Cardiac hypertrophy in CHCHD10S55L mice is apparent relative to WT mice. B. Average heart weight relative to body weight (mg/g). n=7 WT (3 males, 4 females) and n=7 CHCHD10S55L (3 males, 4 females) mice per group. Error bars indicate SEM. ***p<0.001 by Student’s t-test. C. H&E staining of heart sections of WT and CHCHD10S55L mice. Left ventricular wall thickness is increased in CHCHD10S55L heart. Scale bar = 1 mm. D. Kaplan-Meier survival analysis. CHCHD10S55L breeding females (n=5) have shortened lifespan than CHCHD10S55L naïve females (n=5). p=0.0018 by log-rank test. The orange bar indicates the time when females were breeding. E. Hearts of WT naïve and CHCHD10S55L breeding females. F. Left ventricle ejection fraction measured by echocardiogram in WT naïve and CHCHD10S55L breeding female mice at 80–90 days of age. n=5. Error bars indicate SEM. ***p<0.001 by Student’s t-test. G. Images captured from echocardiogram during ventricular diastole and systole. Scale bar = 3 mm.