Figure 8. TDP-43 pathology in mutant CHCHD10 mice.
A. Cardiomyocytes immunolabeled with antibodies against TDP-43 (green) and counterstained with the nuclear probe TOPRO3 (red). The right panels show the merged images. Arrowheads indicate TDP-43 inclusions. B. Cardiomyocytes immunolabeled with antibodies against TDP-43 (green) and TIA-1 (red). The right panels show the merged images. Arrowheads indicate inclusions positive for both TDP-43 and TIA-1. C. Midbrain neurons immunolabeled with antibodies against TDP-43 (green) and TH (red). Arrowheads indicate TDP-43 inclusions. D. Spinal cord motor neurons immunolabeled with antibodies against TDP-43 (green) and ChAT (red). Scale bars = 20 μm.