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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Psychopharmacology (Berl). 2018 Dec 15;236(3):963–971. doi: 10.1007/s00213-018-5145-8

Figure 1.

Figure 1.

Dose-response curves determined from substitution tests with MDPV, MDMA, MDA and the optical isomers of MDMA and MDA in rats trained to discriminate 0.5 mg/kg MDPV from saline. Percentage MDPV-lever selection is depicted by closed symbols in the top panel and response rate is shown as open symbols in the bottom panel. Individual data points represent the group mean (± SEM). N=7 except where noted in parentheses. Statistically significant Dunnett’s tests compared to saline (P < 0.05) are indicated by the letter a [(±)-MDMA or (±)-MDA], b [(+)-MDMA or (+)-MDA], or c [(−)-MDMA or (−)-MDA].