Table 3.
Humanistic burden for patients overall and stratified by ECOG-PS
| Characteristic | Overall (N = 1030) |
Current ECOG performance status | P value | |||
|---|---|---|---|---|---|---|
| 0 n = 200 |
1 n = 448 |
2 n = 282 |
3 or 4 n = 100 |
|||
| EQ-5D-3L utility index, mean (SD) | 0.67 (0.31) | 0.84 (0.20) | 0.74 (0.23) | 0.57 (0.31) | 0.29 (0.4) | < 0.0001a |
| EQ-5D-3L | ||||||
| Mobility domain, % | ||||||
| No/some/extreme problems | 46.2/50.2/3.6 | 71.5/28.0/0.5 | 54.4/44.5/1.1 | 30.1/66.0/3.9 | 4.0/76.0/20.0 | < 0.0001b |
| Self-care, % | ||||||
| No/some/extreme problems | 59.3/36.2/4.5 | 83.4/16.6/0 | 70.9/27.5/1.6 | 41.3/54.4/4.3 | 10.0/63.0/27.0 | < 0.0001b |
| Usual activities, % | ||||||
| No/some/extreme problems | 40.4/52.2/7.4 | 70.4/28.6/1.0 | 45.8/51.7/2.5 | 23.4/66.3/10.3 | 4.0/62.0/34.0 | < 0.0001b |
| Pain/discomfort, % | ||||||
| No/some/extreme problems | 28.1/64.7/7.2 | 52.3/43.7/4.0 | 31.2/64.6/4.3 | 13.1/80.9/6.0 | 8.1/61.6/30.3 | < 0.0001b |
| Anxiety/depression, % | ||||||
| No/some/extreme problems | 35.8/50.1/14.0 | 56.8/33.2/10.1 | 38.2/52.6/9.2 | 25.3/60.1/14.6 | 13.0/45.0/42.0 | < 0.0001b |
| EQ-5D VAS, mean (SD) | 57.4 (18.1) | 68.1 (15.7) | 60.4 (15.7) | 51.6 (17.0) | 39.0 (16.8) | < 0.0001a |
| Employment status, % | < 0.0001b | |||||
| Working full time | 149 (14.7) | 68 (34.3) | 55 (12.5) | 24 (8.7) | 2 (2.0) | |
| Working part time | 65 (6.4) | 15 (7.6) | 40 (9.1) | 7 (2.5) | 3 (3.0) | |
| Unemployed | 105 (10.3) | 20 (10.1) | 48 (10.9) | 25 (9.0) | 12 (12.0) | |
| Student | 1 (0.1) | 0 (0) | 1 (0.2) | 0 (0) | 0 (0) | |
| Homemaker | 82 (8.1) | 20 (10.1) | 36 (8.2) | 18 (6.5) | 8 (8.0) | |
| Retired | 614 (60.4) | 75 (37.9) | 261 (59.2) | 203 (73.3) | 75 (75.0) | |
| WPAI-GH, mean (SD) | ||||||
| % work time missed | 15.2 (24.6) | 11.9 (22.7) | 14.3 (23.3) | 26.6 (32.5) | 27.2 (13.5) | 0.0255a |
| % impairment while working | 31.0 (22.4) | 24.5 (20.0) | 34.1 (21.5) | 36.7 (25.3) | 60.0 (29.4) | 0.0026a |
| % overall work impairment | 36.7 (25.8) | 28.7 (24.2) | 39.2 (23.2) | 48.4 (29.1) | 81.2 (9.8) | 0.0005a |
| % activity impairment | 52.7 (27.9) | 37.1 (26.3) | 49.1 (26.1) | 61.9 (26.2) | 73.6 (21.5) | < 0.0001a |
| EORTC QLQ-C30 domains, mean (SD) | ||||||
| Global health status | 48.1 (19.8) | 56.8 (18.3) | 50.8 (19.2) | 42.5 (18.4) | 34.8 (18.0) | < 0.0001a |
| Physical functioning | 63.5 (25.0) | 78.7 (19.3) | 68.4 (21.4) | 54.3 (24.2) | 36.5 (21.2) | < 0.0001a |
| Role functioning | 57.4 (28.5) | 72.9 (25.3) | 61.9 (25.7) | 48.4 (27.4) | 32.5 (24.4) | < 0.0001a |
| Emotional functioning | 60.4 (24.6) | 69.1 (25.4) | 64.0 (22.0) | 55.6 (23.7) | 40.4 (22.9) | < 0.0001a |
| Cognitive functioning | 70.6 (25.4) | 80.3 (22.3) | 74.1 (23.4) | 64.7 (25.8) | 52.0 (25.1) | < 0.0001a |
| Social functioning | 64.4 (28.1) | 76.3 (26.0) | 68.7 (25.7) | 57.0 (28.1) | 42.0 (24.2) | < 0.0001a |
| Fatigue | 46.3 (25.2) | 30.1 (20.8) | 43.6 (22.8) | 53.1 (23.7) | 71.1 (22.0) | < 0.0001a |
| Nausea and vomiting | 24.0 (23.8) | 20.8 (22.9) | 22.2 (23.2) | 26.3 (24.2) | 32.0 (24.8) | < 0.0001a |
| Pain | 36.1 (25.4) | 23.0 (24.0) | 33.4 (23.8) | 42.0 (23.0) | 58.3 (22.2) | < 0.0001a |
| Dyspnoea | 38.8 (26.6) | 26.6 (24.6) | 35.5 (24.8) | 43.2 (25.0) | 65.3 (21.1) | < 0.0001a |
| Insomnia | 36.4 (28.8) | 26.6 (25.9) | 33.8 (28.4) | 41.2 (28.9) | 54.3 (25.4) | < 0.0001a |
| Appetite loss | 36.5 (28.9) | 26.8 (26.2) | 33.4 (27.5) | 43.0 (30.2) | 51.7 (27.0) | < 0.0001a |
| Constipation | 22.2 (25.1) | 17.8 (21.4) | 19.7 (24.5) | 24.6 (25.1) | 35.3 (29.5) | < 0.0001a |
| Diarrhoea | 13.5 (21.2) | 13.4 (18.9) | 13.3 (21.9) | 13.7 (22.2) | 14.1 (19.7) | 0.7580a |
| Financial difficulties | 22.8 (26.5) | 15.4 (23.2) | 18.7 (24.3) | 29.0 (28.0) | 38.4 (28.3) | < 0.0001a |
EORTC QLQ-C30 EORTC QoL Questionnaire, EQ-5D-3L EuroQol five-dimensional questionnaire three level version, SD standard deviation, VAS visual analogue scale, WPAI-GH work productivity and activity impairment: general health
aKruskal–Wallis test performed
bChi-squared test performed