Table 5.
Humanistic burden for caregivers overall and stratified patient ECOG performance status
| Characteristic | Overall (N = 427) |
Patient ECOG performance status | P value | |||
|---|---|---|---|---|---|---|
| 0 n = 66 |
1 n = 181 |
2 n = 129 |
3 or 4 n = 51 |
|||
| EQ-5D-3L utility index, mean (SD) | 0.89 (0.18) | 0.90 (0.16) | 0.92 (0.13) | 0.87 (0.21) | 0.82 (0.25) | 0.0072a |
| EQ-5D-3L | ||||||
| Mobility domain, % | ||||||
| No/some/extreme problems | 87.3/12.2/0.5 | 86.4/13.6/0 | 90.5/9.5/0 | 86.6/11.8/1.6 | 76.9/23.1/0 | 0.1367b |
| Self-care, % | ||||||
| No/some/extreme problems | 92.2/7.8/0 | 95.5/4.5/0 | 94.4/5.6/0 | 88.2/11.8/0 | 89.7/10.3/0 | 0.1442b |
| Usual activities, % | ||||||
| No/some/extreme problems | 89.1/10.7/0.2 | 90.9/9.1/0 | 90.5/9.5/0 | 87.5/11.7/0.8 | 84.6/15.4/0 | 0.6259b |
| Pain/discomfort, % | ||||||
| No/some/extreme problems | 78.4/21.1/0.5 | 80.3/19.7/0 | 82.1/17.3/0.6 | 76.6/23.4/0 | 64.1/33.3/2.6 | 0.0802b |
| Anxiety/depression, % | ||||||
| No/some/extreme problems | 58.8/32.7/8.5 | 65.2/21.2/13.6 | 62.8/32.2/5.0 | 57.8/31.3/10.9 | 33.3/59.0/7.7 | 0.0150b |
| EQ-5D VAS, mean (SD) | 80.3 (16.8) | 82.1 (16.6) | 82.3 (14.8) | 78.9 (18.6) | 73.1 (17.8) | 0.0186a |
| Employment status, % | 0.0979b | |||||
| Working full time | 152 (36.2) | 25 (39.1) | 68 (37.6) | 43 (34.1) | 16 (32.7) | |
| Working part time | 37 (8.8) | 6 (9.4) | 19 (10.5) | 10 (7.9) | 2 (4.1) | |
| Unemployed | 35 (8.3) | 4 (6.3) | 14 (7.7) | 14 (11.1) | 3 (6.1) | |
| Student | 6 (1.4) | 0 (0) | 2 (1.1) | 4 (3.2) | 0 (0) | |
| Homemaker | 84 (20.0) | 18 (28.1) | 40 (22.1) | 15 (11.9) | 11 (22.4) | |
| Retired | 106 (25.2) | 11 (17.2) | 38 (21.0) | 40 (31.7) | 17 (34.7) | |
| ZBI, mean (SD) | 31.3 (15.0) | 24.5 (13.3) | 30.0 (14.9) | 32.8 (13.8) | 40.8 (15.2) | < 0.0001a |
| ZBI, n (%) | < 0.0001b | |||||
| Little/no burden (0–20) | 103 (24.8) | 25 (38.5) | 44 (24.9) | 29 (23.4) | 5 (10.0) | |
| Mild/moderate burden (21–40) | 200 (48.1) | 34 (52.3) | 88 (49.7) | 59 (47.6) | 19 (38.0) | |
| Moderate/severe burden (41–60) | 101 (24.3) | 6 (9.2) | 41 (23.2) | 34 (27.4) | 20 (40.0) | |
| Severe burden (61–88) | 12 (2.9) | 0 | 4 (2.3) | 2 (1.6) | 6 (12.0) | |
EORTC QLQ-C30 EORTC QoL Questionnaire, EQ-5D-3L EuroQol five-dimensional questionnaire three level version, SD standard deviation, VAS visual analogue scale, WPAI-GH work productivity and activity impairment: general health, ZBI Zarit burden index
aKruskal–Wallis test performed
bChi-squared test performed