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. Author manuscript; available in PMC: 2020 Feb 14.
Published in final edited form as: J Med Chem. 2019 Jan 24;62(3):1562–1576. doi: 10.1021/acs.jmedchem.8b01754

Figure 1.

Figure 1.

aDose response curve of 1 for inhibition of T. gondii DHFR and human DHFR

aThe shaded blue area represents the concentration of 1 with >80% inhibition of TgDHFR and 5 to 35% hDHFR.