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aSynthesis of Compounds 2, 7-18, 20, 21 and 32
R2 = (a) 3-phenyl, (b) hydrogen, (c) 2-phenyl, (d) 4-phenyl, (e) 2-methyl, (f) 3-methyl, (g) 4-methyl, (h) 2-chloro, (i) 3-chloro, (j) 4-chloro, (k) 3-methoxy, (l) 3-trifluoromethyl, (m) 3-trifluoromethoxy, (n) 3-bromo
a Reagents and conditions: (a) KF, DMSO, 110 °C, 12 h; (b) POCl3, DIPEA, 110 °C, 5 h; (c) NH3, EtOH, 145 °C, 24 h
