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. Author manuscript; available in PMC: 2020 Feb 14.
Published in final edited form as: J Med Chem. 2019 Jan 24;62(3):1562–1576. doi: 10.1021/acs.jmedchem.8b01754

Table 2.

aProperties of 1 and 2

Compound MW cLog P Log Pb TPSA cSol (μM)
1 248.7 3.00 2.71 76.8 135
2 346.4 3.74 3.38 83.2 3.09
a

Calculated properties were performed using ChemDraw® Professional software version 17.0.0.206 (121).

b

Measured LogP was performed at pH 11.0 in octanol/buffer.