. Author manuscript; available in PMC: 2020 Feb 14.

Published in final edited form as: J Med Chem. 2019 Jan 24;62(3):1562–1576. doi: 10.1021/acs.jmedchem.8b01754

Table 6.

Parasiticidal activity for 1 and 3 in T. gondii infected human foreskin fibroblast cells as compared to the antiproliferative effects of 1 and 3 in MCF-7 cells

Compound	T. gondii Cell-Based EC₅₀ (nM)^a	MCF-7 EC₅₀ (nM)^b	Selectivity Index^c
3	13 ± 3.8	7300	560
1	680 ± 210	11,700	17

EC₅₀=half maximal response concentration, average of at least 3 experiments (± SD).

MCF-7 cell viability determined using the MTT assay in triplicate (n = 1).

Selectivity index calculated as the MCF-7 EC₅₀/Tg cell-based EC₅₀.