Figure 2.

Funnel plots of the meta-analysis by Andersen et al[26] before (panel A) and after (panel B) applying the trim-and-fill method. The closed dots indicate the observed studies, and the open dots indicate the missing studies imputed by the trim-and-fill method (based on the estimator L0). The dashed lines that create a triangular area indicate the 95% confidence limits (under the fixed-effect setting), and the vertical solid line represents the overall effect size.