Table I. Recovery from severe proteinuria and reduction of morbidity by therapeutic treatment with anti-CD40.
| Group | Total n | Recovered n | Recovery (%) | Days to Recovery (Mean ± SE) | Morbidity (%) |
|---|---|---|---|---|---|
| Vehicle (PBS) | 15 | 0 | 0 | —¶ | 73 |
| Prednisolone | 14 | 3 | 21 | 25 ± 10 | 50 |
| Anti-CD40 | |||||
| 15 mg/kg | 15 | 13 | 87*† | 13 ± 2 | 7‡§ |
| 3 mg/kg | 15 | 8 | 53*† | 13 ± 3 | 33 |
| 0.6 mg/kg | 15 | 1 | 7 | 5 ± 0 | 80 |
| 0.12 mg/kg | 14 | 0 | 0 | —¶ | 64 |
*
p < 0.05 using Fisher exact test compared with vehicle group, †p < 0.05 using Fisher exact test compared with prednisolone group, ‡p < 0.05 using Mantel–Cox survival analysis compared with vehicle group, §p < 0.05 using Mantel–Cox survival analysis compared with prednisolone group, ¶no recovery occurred.