Table 3.
Characteristics of subjects whose levels of lysosomal acid lipase activity were measured before and after VLCKD. Continuous values are expressed as mean ± standard deviation; distributions are expressed as numbers (%).
| Baseline (20 pts) | After VLCKD (20 pts) | p-Value | |
|---|---|---|---|
| Weight, kg | 120 ± 25 | 113 ± 23 | 0.001 |
| Body mass index, kg/m2 | 44 ± 8 | 41 ± 8 | <0.001 |
| Visceral fat area, cm2 | 281 ± 76 | 251 ± 80 | 0.009 |
| Flow-mediated dilation, % | 13 ± 6 | 12 ± 5 | 0.711 |
| LDL-cholesterol, mg/dL | 112 ± 26 | 98 ± 22 | 0.002 |
| Triglycerides, mg/dL | 184 ± 120 | 136 ± 74 | 0.003 |
| Insulin, IU/L | 22.8 ± 22.4 | 14.4 ± 7.8 | 0.007 |
| HOMA index | 5.6 ± 6 | 3.2 ± 2 | 0.009 |
| γGT, IU/L | 41.2 ± 30 | 28.8 ± 15 | 0.008 |
| Liver Steatosis | |||
| No steatosis | 0 (0%) | 2 (10%) | 0.046 |
| Grade 1 | 3 (15%) | 7 (35%) | |
| Grade 2 | 4 (20%) | 3 (15%) | |
| Grade 3 | 13 (65%) | 8 (40%) |