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. 2019 Apr 26;9(5):81. doi: 10.3390/metabo9050081

Figure 4.

Figure 4

A simplified representation of aspartate synthesis from glutamine (a) and glucose (b). Note that in (b), the flux through T4 and GOT 2 can be split in a malate–aspartate shuttle (MAS) with a flux of 2 and in a 1.85 flux through T4 corresponding to aspartate output, i.e., T4 net flux is 3.85. See the complete representation of the glutamine- and glucose-derived aspartate in Figure S4a,b. (c): ETC inhibition (RC34 is inhibited) of aspartate synthesis from glutamine in the absence or presence of the dehydrogenase DH which reoxidizes NADHc. (d) ETC inhibition (RC34 is inhibited) of aspartate synthesis from glucose in the absence or presence of the dehydrogenase DH which reoxidizes NADHc. The ETC inhibition leads to lactate release, or pyruvate release in the presence of DH.