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A simplified representation of nucleotides synthesis from glutamine (a) and glucose (b). Note that in (b), the flux through T4 and GOT 2 can be split, in the malate–aspartate shuttle (MAS) with a flux of 0.74 and in a 0.86 flux corresponding to aspartate recycling. The complete model is in Figure S5a,b in the Supplementary Materials.
