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. 2019 May 14;8(5):674. doi: 10.3390/jcm8050674

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MR regulates IL-6 mRNA expression in pancreatic islet cells. MR mRNA (A) or IL-6 mRNA (B) were measured in αTC cells (p9) transfected with control siRNA (CONMR) or siRNA targeting MR (SiMR) and treated by vehicle (Control, C) or eplerenone and aldosterone (E+A) (n = 4). MR mRNA (C) and IL-6 mRNA (D) were measured in the 1C3 IKEI pancreatic cells (IKEI cells) (p = 3) transfected with empty vector (Control) or human MR-expressing vector (MR+) (n = 4). * p < 0.05. Data are shown as mean ± SE.