Table 2.

Pharmacokinetic parameters of 5 substances in different groups (mean ± SD; n = 10). The pharmacokinetic parameters were calculated according to the blood concentration time of each subject, and then the mean values and SD values of 10 individual pharmacokinetic parameters in each group were calculated. One-way ANOVA and bilateral test were used to compare the pharmacokinetic differences between the compatibility groups and their corresponding groups which the subjects were administered one of the aglycones (* p < 0.05; ** p < 0.01).

	Group	Parameters
		t1/2 (h)	Tmax (h)	Cmax (ng/mL)	AUC0-t	AUC0-∞	AUMC0-∞	MRT0-∞ (h)	V/F (L)	Cl/F (L/h)
					(ng·h/mL)	(ng·h/mL)	(ng·h2/mL)
Aloe-emodin	Aloe-emodin	14.98 ± 6.48	0.32 ± 0.12	9.88 ± 2.9	42.77 ± 10.09	63.18 ± 24.20	1524 ± 566.3	21.73 ± 8.35	4287 ± 1948	244.2 ± 118.0
	Aloe-emodin + Emodin	33.26 ± 6.4 **	0.45 ± 0.11	10.85 ± 1.45	88.02 ± 8.32 **	214.4 ± 14.32 **	9303 ± 703.5 **	45.3 ± 6.39 **	2857 ± 171.6 *	59.6 ± 7.76 **
	Aloe-emodin + Rhein	21.51 ± 6.36	0.55 ± 0.11 **	14.1 ± 3.04 *	77.58 ± 7.3 **	126.6 ± 15.53 **	3323 ± 240.7 **	26.61 ± 5.61	3181 ± 271.5	104.0 ± 12.18 **
	Aloe-emodin+ Chrysophanol	28.34 ± 4.72 **	0.45 ± 0.11	12.41 ± 2.53	99.62 ± 11.7 **	210.4 ± 18.37 **	7955 ± 508.8 **	38.15 ± 5.3 **	2488 ± 330.0 **	62.78 ± 5.30 **
	Aloe-emodin + Physcion	15.49 ± 3.64	0.55 ± 0.11 **	17.8 ± 4.18 **	121.5 ± 19.59 **	177.7 ± 16.70 **	3641 ± 261.1 **	21.2 ± 6.57	1556 ± 262.4 **	75.65 ± 15.29 **
Emodin	Emodin	23.13 ± 3.56	0.75 ± 0.00	91.65 ± 16.82	624.7 ± 73.35	1108 ± 191.1	33673 ± 10503	29.90 ± 4.71	1052 ± 119.8	31.99 ± 5.15
	Emodin + Aloe-emodin	26.13 ± 4.44	0.3 ± 0.11 **	95.15 ± 5.47	419.5 ± 21.62 **	798.8 ± 40.85 **	27693 ± 2767	32.5 ± 5.44	1550 ± 113.0 **	44.82 ± 5.12 **
	Emodin + Rhein	28.97 ± 6.17 *	0.45 ± 0.11 **	77.83 ± 6.2 *	511.8 ± 40.91 **	1194 ± 226.7	45531 ± 5933 **	41.11 ± 5.04 **	1282 ± 165.4 **	30.98 ± 4.08
	Emodin + Chrysophanol	26.73 ± 3.18	0.45 ± 0.11 **	65.19 ± 4.96 **	433.4 ± 33.69 **	906.6 ± 29.35 *	33509 ± 3389	38.18 ± 4.87 **	1475 ± 151.6 **	37.92 ± 4.57
	Emodin + Physcion	5.49 ± 0.78 **	0.5 ± 0 **	91.21 ± 8.89	373.3 ± 54.31 **	397.4 ± 82.77 **	3464 ± 655.3 **	8.64 ± 0.83 **	689.7 ± 49.64 **	87.65 ± 7.74 **
Rhein	Rhein	10.20 ± 2.50	0.23 ± 0.06	19290 ± 5420	18866 ± 1739	20893 ± 2262	157175 ± 52352	7.44 ± 1.87	12.08 ± 2.07	0.83 ± 0.09
	Rhein + Aloe-emodin	5.21 ± 0.89 **	0.6 ± 0.29 **	3136 ± 412.6 **	10272 ± 1478 **	10909 ± 1119 **	71400 ± 5075	7.17 ± 0.78	13.51 ± 1.46	1.56 ± 0.53 **
	Rhein + Emodin	9.26 ± 0.87	0.5 ± 0 **	2554 ± 511.0 **	10861 ± 1055 **	11515 ± 1366 **	116864 ± 16106 **	10.76 ± 1.10 **	18.33 ± 1.19 **	1.47 ± 0.55 *
	Rhein + Chrysophanol	8.98 ± 0.74	0.5 ± 0.18 **	3076 ± 299.8 **	8914 ± 535.7 **	10548 ± 1333 **	92427 ± 5960 *	10.07 ± 1.54 **	21.9 ± 2.25 **	1.98 ± 0.28 **
	Rhein + Physcion	10.8 ± 1.12	0.75 ± 0.18 **	1746 ± 102.8 **	8857 ± 845.1 **	10500 ± 1367 **	124300 ± 17430 **	11.42 ± 1.61 **	24.18 ± 2.45 **	1.72 ± 0.54 **
Chrysophanol	Chrysophanol	37.47 ± 14.54	0.54 ± 0.10	19.01 ± 3.93	88.97 ± 10.58	185.2 ± 56.36	8755 ± 3200	42.24 ± 23.55	10372 ± 2880	236.8 ± 97.59
	Chrysophanol + Aloe-emodin	34.61 ± 4.86	0.65 ± 0.11 **	15.22 ± 4.55	75.17 ± 8.9 **	173.6 ± 11.3	7441 ± 368	44.73 ± 5.03	10815 ± 1527	248.6 ± 40.56
	Chrysophanol + Emodin	47.34 ± 11.03	0.62 ± 0.15 **	8.74 ± 2.09 **	45.87 ± 7.42 **	121.8 ± 15.29 **	7125 ± 450	54.53 ± 9.19	20629 ± 2753 **	313.0 ± 42.9 *
	Chrysophanol + Rhein	38.18 ± 5.76	0.72 ± 0.12 **	9.17 ± 1.49 **	52.47 ± 3.07 **	160.2 ± 4.80	8390 ± 418	57.27 ± 6.35	14625 ± 1072 **	241.8 ± 19.13
	Chrysophanol + Physcion	15.75 ± 2.18 **	0.67 ± 0.13 **	11.8 ± 2.36 **	59.38 ± 4.14 **	96.01 ± 11.77 **	2478 ± 345.7 **	19.06 ± 2.38 **	9866 ± 1354	416.4 ± 48.03 **
Physcion	Physcion	30.47 ± 14.4	0.38 ± 0.14	6.24 ± 0.59	36.38 ± 5.58	72.50 ± 41.70	4492 ± 2151	41.50 ± 17.65	13170 ± 6030	433.4 ± 161.6
	Physcion + Aloe-emodin	26.38 ± 4.99	0.75 ± 0.16 **	6.78 ± 0.81	26.71 ± 4.72 **	48.29 ± 6.73 *	1556 ± 220	32.09 ± 5.62	20255 ± 4540 **	545.1 ± 52.62 *
	Physcion + Emodin	16.65 ± 3.17	0.7 ± 0.11 **	8.05 ± 0.56 **	39.51 ± 2.23	60.89 ± 3.57	1359 ± 156.28	22.82 ± 6.99	10336 ± 1131	436.5 ± 38.8
	Physcion + Rhein	12.88 ± 4.28	0.75 ± 0 **	5.82 ± 0.7	34.51 ± 3.92	45.52 ± 4.41 *	759.2 ± 34.69	16.52 ± 2.82	10773 ± 1823	580.0 ± 46.03 **
	Physcion + Chrysophanol	27.49 ± 2.62	0.75±0 **	9.14 ± 0.37 **	48.45 ± 3.47 **	94.39 ± 5.18	3346 ± 260	35.89 ± 4.75	10747 ± 1803	276.7 ± 16.66 **