Table 3.
The ROC analysis of laboratory findings for different groups and risk assesment according to cut-off values.
| Control vs. DM | ||||||
| Variables | AUC | p-Value | Sensitivity | Specificity | Cut-off Value | OR for Cut-off Values (95%CI) |
| miR-1 | 0.011 | 0.000 | - | - | - | - |
| miR-21 | 0.777 | 0.000 | 0.933 | 0.600 | 0.840 | 21.000 (5.641–78.173) *** |
| NT-proBNP | 0.694 | 0.002 | 0.756 | 0.667 | 95.5 | 6.182 (2.464–15.512) *** |
| Galectin-3 | 0.812 | 0.000 | 0.733 | 0.733 | 4.95 | 7.563 (2.971–19.251)*** |
| Control vs. CAD + DM | ||||||
| Variables | AUC | p-Value | Sensitivity | Specificity | Cut-off value | OR for cut-off Values (95%CI) |
| miR-1 | 0.089 | 0.000 | - | - | - | - |
| miR-21 | 0.944 | 0.000 | 0.800 | 0.911 | 1.130 | 38.875 (10.338–124.488) *** |
| NT-proBNP | 0.988 | 0.000 | 0.956 | 1.000 | 167.5 | X |
| Galectin-3 | 1.000 | 0.000 | 1.000 | 1.000 | 6.200 | X |
| Control vs. HF + DM | ||||||
| Variables | AUC | p-Value | Sensitivity | Specificity | Cut-off Value | OR for Cut-off Values (95% CI) |
| miR-1 | 0.000 | - | - | - | - | - |
| miR-21 | 0.974 | 0.000 | 0.889 | 1.000 | 1.223 | X |
| NT-proBNP | 1.000 | 0.000 | 1.000 | 1.000 | 210.500 | X |
| Galectin-3 | 0.988 | 0.000 | 0.911 | 1.000 | 6.700 | X |
| DM vs. CAD + DM Groups | ||||||
| Variables | AUC | p-Value | Sensitivity | Specificity | Cut-off value | OR for Cut-off Values (95% CI) |
| miR-1 | 0.492 | 0.063 | - | - | - | Not significant |
| miR-21 | 0.755 | 0.000 | 0.778 | 0.667 | 1.168 | 7.0 (2.742–17.867) *** |
| NT-proBNP | 0.976 | 0.000 | 0.956 | 1.000 | 165.5 | X |
| Galectin-3 | 0.891 | 0.000 | 0.800 | 0.822 | 7.150 | 18.5 (6.428–53.245) *** |
| DM vs. HF + DM Groups | ||||||
| Variables | AUC | p-Value | Sensitivity | Specificity | Cut-off Value | OR for Cut-off Values (95%CI) |
| miR-1 | 0.194 | 0.000 | 0.467 | 0.222 | 0.125 | 1.667 (1.175–2.363) *** |
| miR-21 | 0.834 | 0.000 | 0.844 | 0.711 | 1.463 | 12.020 (4.320–33.460) *** |
| NT-proBNP | 1.000 | 0.000 | 1.000 | 1.000 | 208.5 | X |
| Galectin-3 | 0.933 | 0.000 | 0.800 | 1.000 | 8.40 | X |
| CAD + DM vs. HF + DM Groups | ||||||
| Variables | AUC | p-Value | Sensitivity | Specificity | Cut-off Value | OR for Cut-off Values (95%CI) |
| miR-1 | 0.207 | 0.000 | 0.467 | 0.244 | 0.125 | 1.619 (1.137–2.306) *** |
| miR-21 | 0.640 | 0.022 | 0.711 | 0.511 | 1.695 | 2.570 (1.078–6.144) * |
| NT-proBNP | 0.764 | 0.000 | 0.733 | 0.800 | 4747.00 | 11.0 (4.108–29.454) *** |
| Galectin-3 | 0.761 | 0.000 | 0.711 | 0.756 | 9.250 | 7.608 (2.981–19.417) *** |
* p < 0.05; *** p < 0.001; AUC: area uder curve; OR: odds Ratio; X: OR could not be calculated because there were no values above or below the cut-off value in the groups; CI: confidnce interval.