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Rearrangement of the SMAD3 region around p.R74W. (A) Full-length model for the entire SMAD3 structure that shows trimer interaction with position 74 boxed in for emphasis. (B) Wild-type for SMAD3 showing the native conformation for the N-terminus with R74 and K40 for reference. (C) W74 variant for SMAD3 is shown. Here, the rearrangement causes conformational changes including K40 repositioning. Colors, rendering and style are the same as Figure 1.
