Figure 6.

(A) Predicted binding pose of the xanthone 37 (purple sticks) in the binding site of MDM2. (B) MDM2 (transparent surface) in complex with the crystallographic nutlin-3A (1, purple sticks). MDM2 is represented as a transparent surface, where carbon, oxygen, nitrogen, and sulfur are represented in green, red, blue, and yellow, respectively. Small molecule-MDM2 interactions are depicted with a dashed red line. MDM2 residues involved in interactions with the ligands are represented as green sticks and labeled.