Table A1.

ST000061, Representative Pathway Covering Using Constant Cost Function.

Pathway	Metabolites Covered
5-oxo-l-proline metabolism	5-oxo-l-proline, L-glutamate
alpha-tocopherol degradation	alpha-tocopherol
anandamide degradation	arachidonic acid, ethanolamine
histidine degradation	L-glutamate, L-histidine
isoleucine degradation	L-isoleucine, L-glutamate
leucine degradation	L-leucine, L-glutamate
lysine degradation I (saccharopine pathway)	L-glutamate, L-lysine
methionine salvage cycle III	L-methionine, putrescine
NAD de novo biosynthesis	L-tryptophan, L-alanine, L-glutamate
phenylalanine degradation/tyrosine biosynthesis	L-phenylalanine, L-tyrosine
pregnenolone biosynthesis	cholesterol
proline degradation	L-proline, L-glutamate
purine nucleotides degradation	xanthine, guanosine, hypoxanthine, inosine
pyrimidine deoxyribonucleosides degradation	uracil
superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle	2-phospho-d-glycerate, 3-phospho-d-glycerate,
	3-phospho-d-glyceroyl-phosphate, (S)-malate,
	fumarate, citrate, 2,3-diphospho-d-glycerate
superpathway of methionine degradation	L-methionine, L-glutamate, L-serine
threonine degradation	L-threonine
triacylglycerol degradation	glycerol
urea cycle	L-ornithine, fumarate, L-aspartate
valine degradation	L-glutamate, L-valine