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. 2019 Feb 27;151(6):786–797. doi: 10.1085/jgp.201812236

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© 2019 Morales et al.

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Figure 3. — L-type channel inactivation processes during the AP. (A) State diagram of the model for L-type Ca²⁺ channel, the model assumes four closed states (C1, C2, C3, C4), three inactivation states (I1, I2, I3), and one open state (O). Voltage-dependent constants are α and β while γγ is calcium dependent. K_pcf and K_pcb are voltage-insensitive rate constants. (B–D) Probability of open (dark yellow line), closed (violet line), CDI (light purple line), or VDI (pink line) states of LTCCs during a simulated AP simulated in control cardiomyocytes (A) or with reduced VDI (B) or CDI (C). Normalized membrane potential (V_m, black line) for each scenario is shown for comparison.