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. 2019 Feb 27;151(6):786–797. doi: 10.1085/jgp.201812236

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© 2019 Morales et al.

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Figure 5. — APs and L-type calcium currents in CDI-impaired cardiomyocytes. (A) Representative AP waveforms from a newborn rat cardiomyocyte overexpressing CaM_wt (solid black line) or CaM₃₄ (dashed blue line). APs were elicited by 2–5 ms depolarizing current injections (100–200 pA) at 1 Hz. The horizontal line indicates zero level. (B) Bar graph of APD estimated at 20% (APD₂₀), 50% (APD₅₀), and 90% (APD₉₀) of the repolarization phase. (C) Phase plot of the normalized first derivative of membrane potential (dV/dt) against membrane potential (V_m) for the APs shown in A. Empty symbols correspond to data from cardiomyocytes overexpressing CaM_wt and blue symbols for cardiomyocytes overexpressing CaM₃₄. (D) Bar graph of overshoot, threshold potentials, and mean DMPs. (E) Representative nifedipine-sensitive current (solid line) elicited by the AP (dashed line) prerecorded from the same cardiomyocyte overexpressing CaM₃₄. (F) Bar graph of maximal current normalized by cell capacitance (pA/pF), total time of nifedipine-sensitive current normalized by its APD (TTC_norm), and the total current integral normalized by cell capacitance (Q_total). Data are shown as percentages with respect to CaM_wt-overexpressing cardiomyocytes. Bar graphs are mean ± SEM; empty bars represent cardiomyocytes overexpressing CaM_wt, and blue bars correspond to those overexpressing CaM₃₄ (n = 7; *, P < 0.01 with respect to CaM_wt).