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. 2019 Feb 27;151(6):786–797. doi: 10.1085/jgp.201812236

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© 2019 Morales et al.

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Figure 7. — Role of L-type channel inactivation processes during a simulated AP. (A) Simulated L-type calcium current for the control condition (black line) or for cardiomyocytes with increased L-type channel conductance alone (light gray line) or simultaneously with an increased CDI (violet line) or VDI (pink line). (B) Experimental data showing the maximal nifedipine-sensitive current from control, Ca_Vβ_2a, and CaM₃₄ before (empty bars) or after (green bars) isoproterenol stimulation. #, P < 0.01 with respect to control; *, P < 0.01 between values before and after isoproterenol stimulation.