Table 1. Effect of dosing regimen variations on simulated nicotine concentrations in plasma/CSF/ER and on nAChR activation or chaperoning.

Nicotine dose (mg) per cigarette	Total daily cigarettes, intervals	Average [nicotine] in plasma/CSF/ER (nM)	Average nAChR activation on PM	Average activation of nAChR chaperoning in ER
1	12/d, 1 h	112	0.1	0.7
0.5	12/d, 1 h	56	0.05	0.55
0.3	12/d, 1 h	34	0.03	0.44
0.1	12/d, 1 h	11	0.01	0.2
0.05	12/d, 1 h	6	0.006	0.13
3	12/d, 1 h	321	0.23	0.83
1	6/d, 2 h	65	0.06	0.6
1	20/d, 0.8 h	148*	0.13*	0.75*

Results have been averaged over 12 or 16 h. Asterisk (*) denotes 16-h average. The first row (in bold) presents our definition of a standard habit, plotted in Fig. 8. The following five rows show simulations for increasingly “denicotinized” cigarettes. The row presenting a dose of 3 mg might be appropriate for a schizophrenic’s smoking strategy (Miwa et al., 2011).