Table 2.

Inhibitory constants and 50% effective concentrations of peptide agonists in CHO-K1 cells expressing human melanocortin receptors (data from Kievit et al. [24]).

Compound	Binding Assay Ki [nM]				cAMP Assay EC50 [nM]
	hMC1R	hMC3R	hMC4R	hMC5R	hMC1R	hMC3R	hMC4R	hMC5R
α-MSH	0.32	15.5	41.4	332	1.01	1.04	4.7	10.5
MT-II	0.27	24	2.66	23.1	0.2	0.51	0.05	5.33
Setmelanotide	3.9	10	2.1	430	5.8	5.3	0.27	1600
LY2112688	4	35.1	1.84	5160	8.12	10.3	0.09	5760