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. 2019 May 14;24(10):1857. doi: 10.3390/molecules24101857

Scheme 1.

Scheme 1

Synthesis of the target compounds. Reagents and conditions: (i) P2S5, CH3CN, 4–7 h; (ii) NH2NH2.H2O, CH3OH, reflux, 1 h; (iii) NaNO2, 5% HCl, 0–5 °C, 5 h; (iv) HC(OC2H5)3, 100 °C, 6 h; (v) CH3COOH, reflux, 2 h; (vi) NH2CONH2, 170 °C, 4 h.