Table 3.
List of downregulated miRNAs in gastric cancer stem cell. Adjusted p-value < 0.05 was considered as statistically significant.
| ID | Motif | Adjusted p-Value | Functional Relevance in GC |
|---|---|---|---|
| MiR-93 | AGCACTT | 0.017 | OncomiR [92] |
| MiR-302A_MiR-302B_MiR-302C | Tumor suppressor [100,101,102] | ||
| MiR-302D | No data | ||
| MiR-372_MiR-373_ MiR-520C | Tumor suppressor [79] | ||
| MiR-520E_MiR-520A_ MiR-520B _MiR-520D | Tumor suppressor [103] | ||
| MiR-526B | Tumor suppressor [104] | ||
| MiR-149 | GAGCCAG | 0.030 | Tumor suppressor [105] |
| MiR-9 | ACCAAAG | 0.030 | Tumor suppressor [106] |
| MiR-219 | GACAATC | 0.031 | Tumor suppressor [107] |
| MiR-193A_MiR-193B | GGCCAGT | 0.031 | OncomiR [108] |
| MiR-492 | CAGGTCC | 0.031 | No data |
| MiR-142_5P | ACTTTAT | 0.031 | Tumor suppressor [109] |
| MiR-192_MiR-215 | TAGGTCA | 0.039 | Tumor suppressor [110] |
If not indicated, the motif could target the 5’ arm, the 3’ arm or both. GC: Gastric cancer; MiR: microRNA; OncomiR: oncogenic microRNA.