Table 1.
Baseline patient characteristics.
| Slow Metabolizers (n = 253) | Fast Metabolizers (n = 148) | p-Value | |
|---|---|---|---|
| Tac mean trough level at 3 months (ng/mL) | 8.6 ± 2.8 | 7.1 ± 2.7 | <0.001 a |
| Tac daily dose at 3 months (mg/day) | 4.9 ± 2.3 | 10.3 ± 4.3 | <0.001 a |
| Age (years, mean ± SD) | 53.0 ± 13.4 | 50.2 ± 13.8 | 0.051 a |
| Male sex, n (%) | 156 (61.7) | 80 (54.1) | 0.142 c |
| BMI (kg/m2, mean ± SD) | 25.2 ± 4.0 | 25.2 ± 4.1 | 0.944 a |
| Pre-existing recipient hypertension, n (%) | 239 (94.5) | 139 (94.6) | 1.000 c |
| Pre-existing recipient diabetes, n (%) | 33 (13.0) | 16 (10.9) | 0.636 c |
| Diagnosis of ESRD, n (%) | 0.411 c | ||
| Hypertension | 20 (7.9) | 11 (7.4) | |
| Diabetes | 11 (4.3) | 1 (0.7) | |
| Polycystic kidney disease | 36 (14.2) | 26 (17.6) | |
| Obstructive Nephropathy | 20 (7.9) | 14 (9.5) | |
| Glomerulonephritis | 103 (40.7) | 53 (35.8) | |
| FSGS | 6 (2.4) | 5 (3.4) | |
| Interstitial nephritis | 4 (1.6) | 2 (1.4) | |
| Vasculitis | 5 (2.0) | 2 (1.4) | |
| Other | 45 (17.8) | 34 (23.0) | |
| Time on dialysis (months, median (IQR)) | 60.5 (25.5, 90.3) | 52.5 (24.9, 87.1) | 0.323 b |
| ≥ 1 prior kidney transplant, n (%) | 39 (15.4) | 19 (12.8) | 0.557 c |
| Living donor transplantation | 58 (22.9) | 44 (29.7) | 0.4 c |
| Number HLA mismatch, n (%) | 1.000 c | ||
| 0–3 | 169 (67.1) | 98 (66.7) | |
| 4–6 | 83 (32.9) | 49 (33.3) | |
| Current PRA, n (%) | 1.000 c | ||
| 0–20% | 248 (98.0) | 145 (98.0) | |
| > 20% | 5 (2.0) | 3 (2.0) | |
| Induction, n (%) | 0.163 c | ||
| Basiliximab | 233 (92.1) | 130 (87.8) | |
| Thymoglobulin | 20 (7.9) | 18 (12.2) | |
| Cold ischaemia time (hours, mean ± SD) | 8.7 ± 4.9 | 8.2 ± 5.4 | 0.419 a |
| Warm ischaemia time (min, mean ± SD) | 31.8 ± 6.9 | 32.2 ± 8.0 | 0.684 a |
| Donor age (years, mean ± SD) | 53.4 ± 16.6 | 54.7 (13.7) | 0.394 a |
| Donor male sex, n (%) | 121 (47.8) | 63 (42.6) | 0.350 c |
Demographic characteristics of the study population by the Tac metabolization status. Results are presented as mean ± standard deviation (SD) or median and first and third quartile (IQR), respectively, or as absolute and relative frequencies. BMI = body mass index; ESRD = end-stage renal disease; FSGS = focal segmental glomerulosclerosis; HLA = human leukocyte antigen; PRA = panel reactive antibodies. a Student’s t-test, b Mann-Whitney U test, c Fisher’s exact test.