Table 2.

Univariable and multivariable analyses of patient survival using Cox regression.

Parameters	Univariable		Multivariable
	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Fast metabolizers vs. slow metabolizers (ref.)	2.209 (1.034–4.719)	0.041	5.749 (1.556–21.242)	0.004
Age (years)	1.057 (1.023–1.093)	0.001	-	0.081
Recipient sex Male vs. female (ref.)	1.631 (0.714–3.727)	0.246	-	0.262
Recipient BMI (kg/m2)	0.942 (0.852–1.042)	0.248	-	0.213
Pre-existing recipient hypertension yes vs. no (ref.)	1.512 (0.205–11.142)	0.685	-	0.635
Pre-existing recipient diabetes yes vs. no (ref.)	2.206 (0.890–5.468)	0.087	-	0.691
Cause of ESRD	-	0.852	-	0.738
Time on dialysis (months)	1.002 (0.993–1.011)	0.714	-	0.553
Prior kidney transplantation ≥1 vs. 0 (ref.)	1.379 (0.522–3.641)	0.517	-	0.707
Donor type Postmortal vs. living donor (ref.)	2.832 (0.853–9.405)	0.089	-	0.936
Number HLA mismatch 4–6 vs. 0–3	2.335 (1.097–4.968)	0.028	-	0.053
Current PRA >20% vs. 0–20%	1.951 (0.265–14.387)	0.512	-	0.709
Cold ischemia time (hours)	1.042 (0.972–1.118)	0.245	-	0.668
Donor age (years)	1.043 (1.014–1.074)	0.004	-	0.540
Donor sex Male vs. female (ref.)	0.928 (0.434–1.982)	0.847	-	0.266
NODAT yes vs. no (ref.)	2.983 (1.396–6.373)	0.005	5.150 (1.550–17.110)	0.005
CMV DNAaemia yes vs. no (ref.)	0.832 (0.352–1.968)	0.676	-	0.629
Acute rejection within 1 year yes vs. no (ref.)	1.610 (0.680–3.807)	0.279	-	0.947
eGFR at month 3 (mL/min/1.73m2)	0.979 (0.960–0.998)	0.028	-	0.999
eGFR at month 12 (mL/min/1.73m2)	0.968 (0.937–1.000)	0.047	-	0.166

Results are presented as hazard ratios (HR) with their 95% confidence interval (CI) and p-value of likelihood ratio test. For non-selected variables in multivariable analyses, p-value of score test is given. HR = hazard ratio; CI = confidence interval.