Table 5.
(a) Univariable Analysis: eGFR at month 12 and linear time-trends of eGFR (between months 12 and 60) by subgroup/marker. (b) Multivariable Analysis: eGFR at month 12 and linear time-trends of eGFR (between month 12 and 60) by subgroup/marker.
| (a) | ||||
| Variable | B | 95% CI | p | |
| Metabolizer type | ||||
| Fast vs. slow (at month 12) | −3.54 | −8.57 to 1.49 | 0.167 | |
| Fast vs slow (time-trends) | −1.07 | −2.10 to −0.05 | 0.040 | |
| R_Sex | ||||
| Male vs. female (at month 12) | −16.21 | −1.26 to −11.61 | <0.001 | |
| Male vs. female (time-trends) | 0.49 | −0.49 to 1.47 | 0.325 | |
| PreHypertension | ||||
| No vs. yes (at month 12) | 0.78 | −9.63 to 11.19 | 0.883 | |
| No vs. yes (time-trends) | 1.26 | −0.79 to 0.20 | 0.240 | |
| PreDiabetes | ||||
| No vs. yes (at month 12) | 4.52 | −3.04 to 12.08 | 0.241 | |
| No vs. yes (time-trends) | 0.91 | −0.68 to 2.51 | 0.262 | |
| Cause of ESRD | ||||
| Cause of ESRD (at month 12) | - | - | 0.010 * | |
| Diabetes vs. Hypertension (at month 12) | 3.72 | −15.38 to 22.82 | 0.703 | |
| Polycystic kidney disease vs. Hypertension (at month 12) | 8.30 | −1.90 to 18.50 | 0.111 | |
| Obstructive Nephropahty vs. Hypertension (at month 12) | 16.20 | 4.91 to 27.48 | 0.005 | |
| Glomerulonephritis vs. Hypertension (at month 12) | 5.82 | −3.12 to 14.76 | 0.202 | |
| FSGS vs. Hypertension (at month 12) | 7.14 | −10.58 to 24.85 | 0.429 | |
| Interstitial nephritis vs. Hypertension (at month 12) | 11.40 | −8.85 to 31.65 | 0.269 | |
| Vasculitis vs. Hypertension (at month 12) | 2.51 | −16.28 to 21.32 | 0.792 | |
| Other vs. Hypertension (at month 12) | 16.81 | 7.14 to 26.48 | 0.001 | |
| Cause of ESRD (time-trends) | - | - | 0.998 * | |
| PriorTx | ||||
| No vs. yes (at month 12) | −8.67 | −15.48 to −1.86 | 0.013 | |
| No vs. yes (time-trends) | 0.25 | −1.13 to 1.63 | 0.719 | |
| DonorType | ||||
| Postmortal vs. Living (at month 12) | −11.15 | −16.40 to −5.90 | <0.001 | |
| Postmortal vs. Living ( time-trends) | 0.47 | −0.60 to 1.55 | 0.387 | |
| HLA Mismatch | ||||
| 0–3 vs. 4–6 (at month 12) | 5.45 | 0.37 to 10.53 | 0.035 | |
| 0–3 vs. 4–6 (time-trends) | −0.21 | −1.25 to 0.83 | 0.696 | |
| CurrentPRA | ||||
| 0–20 vs. >20 (at month 12) | −14.81 | −32.19 to 2.57 | 0.095 | |
| 0–20 vs. >20 (time-trends) | −0.80 | −4.15 to 2.54 | 0.638 | |
| D_Sex | ||||
| Male vs. female (at month 12) | 4.31 | −0.47 to 9.09 | 0.077 | |
| Male vs. female (time-trends) | −0.36 | −1.32 to 0.62 | 0.470 | |
| NODAT | ||||
| No vs. yes (at month 12) | 6.50 | 1.31 to 11.69 | 0.014 | |
| No vs. yes (time-trends) | 0.52 | −0.56 to 1.60 | 0.342 | |
| CMV DNAaemia | ||||
| No vs. yes (at month 12) | 4.46 | −0.74 to 9.66 | 0.093 | |
| No vs. yes (time-trends) | −0.26 | −1.32 to 0.80 | 0.629 | |
| Acute rejection 1 year post RTx | ||||
| No vs. yes (at month 12) | 16.23 | 10.34 to 22.13 | <0.001 | |
| No vs. yes (time-trends) | 0.09 | −1.18 to 1.35 | 0.893 | |
| R-Age (years) | ||||
| R-Age (at month 12) | −0.47 | −0.63 to −0.32 | <0.001 | |
| R-Age (time-trends) | −0.004 | −0.013 to 0.005 | 0.415 | |
| R-BMI | ||||
| R-BMI (at month 12) | −1.12 | −1.67 to −0.57 | <0.001 | |
| R-BMI (time-trends) | −0.008 | −0.027 to 0.011 | 0.405 | |
| Time on Dialysis (month) | ||||
| Time on Dialysis (at month 12) | −0.05 | −0.11 to 0.01 | 0.112 | |
| Time on Dialysis (time-trends) | −0.012 | −0.008 to 0.006 | 0.743 | |
| CIT (hours) | ||||
| CIT (at month 12) | −0.43 | −0.86 to 0.004 | 0.052 | |
| CIT (time-trends) | −0.014 | −0.064 to 0.034 | 0.565 | |
| D_Age (years) | ||||
| D-Age (at month 12) | −0.65 | −0.78 to −0.52 | <0.001 | |
| D-Age (time-trends) | −0.006 | −0.015 to 0.002 | 0.152 | |
| (b) | ||||
| Variable | Estimate | 95% CI | p | |
| At month 12 | ||||
| Metabolizer type: fast vs. slow | −2.48 | −6.47 to 1.51 | 0.222 | |
| D_Age (years) | −0.60 | −0.71 to −0.48 | <0.001 | |
| R_Sex: male vs. female | −12.27 | −15.75 to −8.79 | <0.001 | |
| Donor type: postmortem vs. living | −10.03 | −13.94 to −6.12 | <0.001 | |
| R_BMI (kg/m2) | −0.58 | −1.03 to −0.14 | 0.010 | |
| PreHypertension: no vs. yes | N/S: 0.051 | |||
| PreDiabetes: no vs. yes | N/S: 0.914 | |||
Cause of ESRD
|
10.79 4.72 11.34 2.83 5.16 2.23 −0.31 11.26 |
−2.08 to 23.65 −2.57 to 12.02 3.11 to 19.56 −3.53 to 9.19 −6.98 to 17.31 −14.60 to 19.06 −13.54 to 12.93 4.30 to 18.22 |
0.010 * 0.100 0.204 0.007 0.382 0.404 0.794 0.964 0.002 |
|
| PriorTx: no vs yes | N/S: 0.225 | |||
| HLAMismatch: 0–3 vs. 4–6 | N/S: 0.713 | |||
| CurrentPRA: 0–20 vs. >20 | N/S: 0.272 | |||
| D_Sex: male vs. female | N/S: 0.107 | |||
| NODAT: no vs. yes | N/S: 0.995 | |||
| CMV DNAaemia: no vs. yes | N/S: 0.417 | |||
| Acute rejection 1 year post RTx: no vs. yes | 14.00 | 9.64 to 18.36 | <0.001 | |
| R_Age (years) | N/S: 0.495 | |||
| Time Dialysis (months) | N/S: 0.112 | |||
| CIT (hours) | N/S: 0.771 | |||
| Time trends | ||||
| Metabolizer type: fast vs. slow | −1.07 | −2.05 to −0.09 | 0.032 | |
| D_Age (years) | N/S: 0.121 | |||
| R_Sex: male vs. female | N/S: 0.240 | |||
| Donor Type: postmortem vs. living | N/S: 0.666 | |||
| R_BMI (kg/m2) | N/S: 0.810 | |||
| PreHypertension: no vs. yes | N/S: 0.366 | |||
| PreDiabetes: no vs. yes | N/S: 0.354 | |||
| Cause of ESRD | N/S: 0.997 * | |||
| PriorTx: no vs. yes | N/S: 0.635 | |||
| HLAMismatch: 0–3 vs. 4–6 | N/S: 0.299 | |||
| CurrentPRA: 0–20 vs. >20 | N/S: 0.708 | |||
| D_Sex: male vs. female | N/S: 0.293 | |||
| NODAT: no vs. yes | N/S: 0.368 | |||
| CMV DNAaemia: no vs. yes | N/S: 0.519 | |||
| Acute rejection1 year post RTx: no vs. yes | N/S: 0.913 | |||
| R_Age (years) | N/S: 0.332 | |||
| Time Dialysis (months) | N/S: 0.840 | |||
| CIT (hours) | N/S: 0.400 | |||
* p-value of F-test (global test).