Table 6.
Cox regression model for rejection-free survival. Univariable and multivariable analyses of rejection-free survival using Cox regression. Results are presented as hazard ratios (HR) with their 95% confidence interval (CI) and p-value of likelihood ratio test. For non-selected variables in multivariable analyses, p-value of score test is given.
| Parameters | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Fast metabolizers vs. slow metabolizers (ref.) |
1.536 (1.034–2.282) | 0.035 | 1.622 (1.085–2.424) | 0.020 |
| Age (years) | 0.996 (0.981–1.010) | 0.547 | - | 0.615 |
| Recipient sex Male vs. female (ref.) |
1.432 (0.943–2.176) | 0.092 | - | 0.122 |
| Recipient BMI (kg/m2) | 1.057 (1.007–1.110) | 0.026 | 1.073 (1.021–1.128) | 0.006 |
| Pre-existing recipient hypertension yes vs. no (ref.) |
1.379 (0.507–3.751) | 0.529 | - | 0.695 |
| Pre-existing recipient diabetes yes vs. no (ref.) |
1.032 (0.564–1.887) | 0.919 | - | 0.716 |
| Cause of ESRD | - | 0.999 | - | 0.998 |
| Time on dialysis (months) | 1.000 (0.996–1.005) | 0.862 | - | 0.746 |
| Prior kidney transplantation ≥1 vs. 0 (ref.) |
1.632 (0.999–2.665) | 0.051 | 1.850 (1.109–3.087) | 0.027 |
| Donor type Postmortem vs. living donor (ref.) |
0.765 (0.498–1.174) | 0.220 | - | 0.249 |
| Number HLA mismatch 4–6 vs. 0–3 |
1.043 (0.683–1.593) | 0.845 | - | 0.905 |
| Current PRA >20% vs. 0–20% |
1.033 (0.255–4.189) | 0.964 | - | 0.830 |
| Cold ischaemia time (hours) | 0.986 (0.948–1.026) | 0.489 | - | 0.620 |
| Donor age (years) | 1.002 (0.989–1.014) | 0.788 | - | 0.846 |
| Donor sex Male vs. female (ref.) |
0.936 (0.629–1.391) | 0.742 | - | 0.632 |
HR = hazard ratio; CI = confidence interval.