Table 2.

Effect of formulation (medium chain triglycerides (MCT-SNEDDS)) composition on the dispersibility, precipitation, appearance, and particle size (mean ± S.D., n = 3) for the lipophilic drug chlorpromazine when added to dispersion media simulated intestinal fluid (SIF) pH 6.8 (gentle agitation was provided by a dissolution paddle rotating at 60 rpm).

Code	Composition (% w/w)					Dispersion Time	Precipitation	Appearance	Particle Size
	Captex 355	Tween 85	Ethanol	Drug	Glycerol	s			nm
MCT1	60	25	5	2	8	140 ± 20	White	Stable	911 ± 41
MCT2	55	30	5	2	8	112 ± 15	White	Unstable	921 ± 18
MCT3	50	35	5	2	8	98 ± 26	White	Unstable	522 ± 21
MCT4	45	40	5	2	8	74 ± 27	White	Stable	531 ± 34
MCT5	40	45	5	2	8	67 ± 19	White	Unstable	238 ± 28
MCT6	35	50	5	2	8	17 ± 4	White	Stable	186 ± 20
MCT7	55	25	5	2	13	109 ± 31	White	Unstable	915 ± 19
MCT8	50	30	5	2	13	83 ± 18	White	Unstable	732 ± 43
MCT9	45	35	5	2	13	76 ± 25	White	Unstable	554 ± 32
MCT10	40	40	5	2	13	63 ± 17	White	Unstable	428 ± 29
MCT11	35	45	5	2	13	41 ± 12	White	Stable	334 ± 21
MCT12	50	33	5	2	10	77 ± 10	White	Unstable	919 ± 17
MCT13	45	38	5	2	10	66 ± 11	White	Unstable	465 ± 18
MCT14	40	43	5	2	10	43 ± 16	White	Stable	365 ± 38
MCT15	35	48	5	2	10	37 ± 17	White	Stable	219 ± 18