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. 2019 May 11;11(5):229. doi: 10.3390/pharmaceutics11050229

Figure 2.

Figure 2

Serum norovirus (NoV)-specific IgG titration. Individual termination serum of each mouse in experimental groups immunized with 0.3 µg NoV VLPs alone or mixed with 10 µg of VP6, and the control group (Ctrl, PBS only) were two-fold diluted for analyzing NoV (A) GI.4- and (B) GII.4-2006a-specific IgG antibodies. Shown are mean titration curves for each group and standard errors of the mean. Dashed line indicates positivity cut-off (OD > 0.1). IgG end-point titers against (C) GI.4 and (D) GII.4-2006a VLPs were determined as the reciprocal of the highest serum sample dilution giving a positive reading. Shown are geometric mean titers with 95% confidence interval of each group. Groups were compared by Mann–Whitney U-test and p values were determined.