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Serum norovirus (NoV)-specific IgG1 and IgG2a subtypes. Pooled termination sera of experimental groups immunized with 0.3 µg NoV GI.4 and GII.4-2006a VLPs alone or mixed with 10 µg VP6, and the control group (Ctrl, PBS only) were two-fold diluted for analyzing NoV (A,C) GI.4 and (B,D) GII.4-2006a-specific IgG1 and IgG2a. Shown are titration curves with standard error of the mean. Dashed line indicates positivity cut-off (OD ≥ 0.1).
