Figure 4.

Relative enrichment of compounds with and without a target and with and without an encoded chemical entity: (a) Family AA; (b) Family BF. Enrichment was observed to be both target- and encoded chemistry-dependent: When the encoded chemical entity was cleaved from the library, no enrichment was observed. Thus, we ruled out encoding DNA–target DNA complementarity as being responsible for the observed enrichment in Figure 1; Figure 2. The y axis represents a metric of enrichment significance (ENRv1) for each disynthon (negative log₁₀ of the asymptotic significance value).