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. 2019 May 27;24(10):2026. doi: 10.3390/molecules24102026

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PCR-stop assay. (a) Schematic of the assay: Priming of Pu27 c-myc G4 template amplification by Pu27rev oligonucleotides, which was complementary to the 3′ end portion of C-myc G4. Hybridization occurred if no G-quartet structure formed and a 43-mer extended primer was generated. If the G-Quartet was stabilized by the added small-moleculethen hybridization and subsequent primer extension were inhibited. (b) A dose-dependent reduction in quantity of primer extension product was observed with Compounds 1 and 2, whereas no inhibition was observed with Compound 3, which was used as a negative control (Figure S1). Full gels are presented in Figure S5.