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Dose–response curves for compounds 1–5 and m7Gp3G plotted from a competition binding assay for meIF4E [16]. eIF4E (75 nM) and a pyrene-labeled fluorescent probe (10 nM) were incubated at 30 °C with the indicated concentrations of the investigated compounds (1–5 or m7Gp3G as a reference). IC50 and KD values from triplicate experiments are shown in Table 1.
