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KD values of the binding affinities for murine eIF4E and human DcpS determined by MST. KD values were calculated from triplicate experiments.
| Compound | meIF4E | hDcpS | ||
|---|---|---|---|---|
| KD [nM] | Confidence Interval | KD [nM] | Confidence Interval | |
| 6 | 50 | (43, 58) | n.d. | n.d. |
| 11 | 201 | (184, 220) | 38 | (28, 51) |
| 12 | 53 | (46, 62) | 14 | (7, 24) |
