Table 2.
Follow-up of the patients included in the study.
| Variables | Whole Cohort | Opportunistic Infections Group | Control Group | p-Value |
|---|---|---|---|---|
| n = 538 (100%) | n = 72 (13%) | n = 466 (87%) | ||
| New onset diabetes after transplantation, n (%) | 34 (6) | 5 (7) | 29 (6) | 0.82 |
| Acute rejection, n (%) | 136 (25) | 23 (32) | 113 (24) | 0.19 |
| T-cell mediated, n (%) | 87 (16) | 15 (21) | 72 (16) | 0.54 |
| Antibody-mediated, n (%) | 34 (6) | 6 (8) | 28 (6) | 0.54 |
| Mixed, n (%) | 15 (3) | 2 (3) | 13 (3) | 0.54 |
| Time from transplantation, months (median, IQR) | 5 (2–18) | 7 (3–35) | 4 (2–14) | 0.14 |
| Before opportunistic infection, n (%) | 127 (24) | 15 (21) | 112 (24) | 0.66 |
| Viral Infections | ||||
| BK viruria | 163 (30) | 26 (36) | 137 (29) | 0.25 |
| Time from transplantation, months (median, IQR) | 6 (3–17) | 7 (3–12) | 6 (3–21) | 0.83 |
| Before opportunistic infection, n (%) | 149 (28) | 16 (22) | 133 (28) | 0.32 |
| BK viremia | 58 (11) | 22 (31) | 36 (8) | 0.0001 |
| Time from transplantation, months (median, IQR) | 5 (3–8) | 6 (3–12) | 4 (3–6) | 0.14 |
| Before opportunistic infection, n (%) | ||||
| CMV viremia | 178 (33) | 30 (42) | 148 (32) | 0.10 |
| Time from transplantation, CMV viremia (months, median, IQR) | 4 (2–7) | 5 (2–11) | 3 (2–7) | 0.22 |
| Before opportunistic infection, n (%) | 161 (30) | 17 (24) | 144 (31) | 0.27 |
| 12-month follow-up | ||||
| eGFR mL/min/1.73 m² (median, IQR) | 48 (36–60) | 41 (31–53) | 48 (37–61) | 0.003 |
| Allograft loss, n (%) | 19 (4) | 5 (7) | 14 (3) | 0.09 |
| Time from transplantation, months (median, IQR) | 7 (5–11) | 10 (7–11) | 6 (3–10) | 0.252 |
| Death, n (%) | 16 (3) | 3 (4) | 13 (3) | 0.52 |
| Time from transplantation, months (median, IQR) | 6 (2–9) | 6 (5–7) | 5 (2–9) | 0.95 |
| Last follow-up | ||||
| Time from transplantation, months (median, IQR) | 52 (38–75) | 48 (34–68) | 53 (38–77) | 0.045 |
| eGFR mL/min/1.73 m² (median, IQR) | 45 (36–60) | 38 (29–52) | 46 (34–62) | 0.0009 |
| Allograft loss, n (%) | 68 (13) | 13 (18) | 55 (12) | 0.14 |
| Time from transplantation, months (median, IQR) | 34 (13–54) | 31 (110–48) | 34 (14–55) | 0.81 |
| Death, n (%) | 65 (12) | 10 (14) | 55 (12) | 0.64 |
| Time from transplantation, months (median, IQR) | 34 (13–51) | 29.9 (6–51) | 34 (14–55) | 0.58 |