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. 2019 May 11;8(5):659. doi: 10.3390/jcm8050659

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ISO-induced MI and post-MI cardiac fibrosis of rats. (A) Protocol of ISO-induced MI in rats. (B) HW/BW ratios in ISO-treated and control rats. (C) Serum NT-proBNP levels are increased in ISO-treated rats. (D) Heart sections of ISO-treated rats exhibited more collagen areas than control rats. (E) Serum CXCL9 levels are increased in ISO-treated rats. (F) Serum CCL20 levels in ISO-treated rats are not significantly increased compared to control rats. BW = body weight; CTL = control; HW = heart weight; IP = intraperitoneal; ISO = isoproterenol; MI = myocardial infarction; NT-proBNP = N-terminal prohormone of brain natriuretic peptide. Results are presented as mean ± SEM.