Table 4.

Conversion of methyl 2-aminothiazole-5-carboxylate (1a) to methyl thiazole-5-carboxylate (2a) at various temperatures and reactor coil sizes in THF.

Coil Volume/mL	Residence Time/min	Temperature/°C	Conversion (%)
5		60	41
	10	90	55
		120	73
		60	50
10	20	90	61
		120	88
		60	59
20	40	90	76
		120	87

All experiments were: methyl 2-aminothiazole-5-carboxylate (1.0 mmol) in THF (10 mL), iso-pentyl nitrite (1.2 mmol) in THF (10 mL), both flowing at 0.25 mL min⁻¹ through the stated coil reactor (1 mm i.d.) at the stated temperature. The conversions were calculated by integration of product ¹H-NMR peaks relative to a quantified internal standard of nitrobenzene.