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Dose-survival curves of PC9 (A) and A549 (B) cells treated with varying cisplatin and radiation doses with or without propranolol. Propranolol was administered at 0, 1, or 50 micromolar (μM) to PC9 and A459 cells immediately before cisplatin exposure or irradiation (gray (Gy)). In clonogenic survival assays, propranolol (50 μM) significantly sensitizes tumor cells to cisplatin and radiation when compared to untreated (no propranolol) cells. * p < 0.05.
