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. 2019 May 16;11(5):896. doi: 10.3390/polym11050896

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Confocal microscopy images of KB cells preincubated for 1.5, 6, and 24 h with SpAcDex(TPP) particles without and with FA conjugated on the surface. All particles were incubated in a concentration of 20 µg/mL. SpAcDex(TPP)-FA particles were additionally incubated without (-) and with (+) 1 mM folic acid as a competitor for FRα. Both ligand-free SpAcDex and FA-modified particles are time-dependently taken up by the cells (left and central columns). However, the uptake of SpAcDex(TPP)-FA particles in the presence of 1 mM FA is significantly reduced (right column). See Supplementary Data for single channel TPP, DAPI, and transmission images.