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. 2019 May 27;24(10):2022. doi: 10.3390/molecules24102022

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The average number of tubes formed among HUVECs after 8 h of incubation on growth factor reduced BD matrigel, in which * represents a significant difference (p ≤ 0.05 and ** p ≤ 0.01) from the control group, which was calculated using Graph-Pad Prism 7.03 to determine the significance between each experimental group and control. ^# represents a significant difference (p ≤ 0.05) among treated groups and VEGF positive control. (B) Representative images are shown for the treatment with growth media alone, 0.1 µg/mL, and 1 µg/mL hypermongone C. Fewer tubes were formed in the group including untreated cells, with many of them remaining as individual single cells.