Table 1.
Study characteristics of the rs700651 variant in multi-ethnic populations.
| Study First Author (Year) | Population | Case/Control | Female | Age a | N/R b | RAF b | OR (95% CI) c | p | Adjusted Covariates |
|---|---|---|---|---|---|---|---|---|---|
| Bilguvar (2008) [20] | FIN | 874/944 | NA | NA | A/G | 0.390/0.440 | 1.210 (1.057–1.386) | 0.0058 | NA |
| DUT | 706/5332 | NA | NA | A/G | 0.350/0.400 | 1.230 (1.093–1.384) | 5.8 × 10−4 | NA | |
| JPT | 495/676 | NA | NA | A/G | 0.540/0.460 | 1.300 (1.107–1.526) | 0.0011 | NA | |
| Deka (2010) [21] | CEU | 406/392 | 53.3 (45.7%) | 50.5/63.4 | A/G | 0.340/0.339 | 1.000 (0.808–1.237) | 0.973 | age |
| Hashikata (2010) [22] | JPT | 419/408 | 66.1 (52.0%) | 60.5/60.0 | A/G | 0.484/0.463 | 1.140 (0.940–1.390) | 0.19 | sex, age, smoking, HTN |
| Low (2012) [5] | JPT | 1359/5464 | 64.7 (42.7%) | 60.1/56.9 | A/G | 0.490/0.488 | 1.001 (0.919–1.091) | 0.975 | sex, age, PCs |
| Hong (2019) [11] | KOR | 254/290 | 58.4 (52.0%) | 59.3/52.1 | A/G | 0.476/0.449 | 1.415 (1.095–1.829) | 0.0079 | sex, age, smoking, HTN |
CEU: Caucasian; DUT: Dutch; FIN: Finnish; GWAS: genome-wide association study; HLP: hyperlipidemia; HTN: hypertension; JPT: Japanese in Tokyo; KOR: Korean; NA: not available; PC: principal component; a Mean age of the case (left) and control (right) groups; b N/R: non-risk/risk allele type; RAF: risk allele frequency in the case (left) and control (right) groups; c odds ratio (OR), 95% confidence interval (CI), and p-values were estimated by multivariate logistic regression after adjustment for study-specific covariates under an additive effect model.