Table 2.
rs700651 (2q33.1) in multi-ethnic meta-analysis.
| No. Studies a | Population | Effect Model | RAF b | OR (95% CI) c | p | Heterogeneity (I2), % | p for Heterogeneity |
|---|---|---|---|---|---|---|---|
| European Ancestry | |||||||
| 3 [20,21] | 3 EUR | Fixed | 0.403 | 1.186 (1.092–1.287) | 4.83 × 10−5 | 31.26 | 0.2335 |
| Random | 1.175 (1.061–1.302) | 0.0020 | |||||
| East-Asian | |||||||
| 3 [5,20,22] | 3 JPT | Fixed | 0.482 | 1.071 (0.998–1.149) | 0.0571 | 76.16 | 0.0151 |
| Radom | 1.128 (0.952–1.337) | 0.1624 | |||||
| 4 [5,11,20,22] | 3 JPT, 1 KOR | Fixed | 0.480 | 1.092 (1.020–1.168) | 0.0112 | 76.23 | 0.0055 |
| Random | 1.179 (0.999–1.392) | 0.0513 | |||||
| 3 [11,20,22] | 2 JPT, 1 KOR | Fixed, random | 0.459 | 1.264 (1.131–1.413) | 3.60 × 10−5 | 0.00 | 0.3749 |
| European + East-Asian | |||||||
| 7 [5,11,20,21,22] | 3 EUR, 3 JPT, 1 KOR | Fixed | 0.443 | 1.129 (1.071–1.189) | 5.57 × 10−6 | 66.37 | 0.0066 |
| Random | 1.164 (1.055–1.284) | 0.0025 | |||||
| 6 [11,20,21,22] | 3 EUR, 2 JPT, 1 KOR | Fixed | 0.415 | 1.213 (1.135–1.296) | 1.05 × 10−8 | 12.35 | 0.3361 |
| Random | 1.212 (1.128–1.302) | 1.65 × 10−7 |
a The number of studies involved in each meta-analysis; b The average RAF in the control group was calculated using the Genome-Wide Association Meta-Analysis (GWAMA) software; c odds ratio (OR), 95% confidence interval (CI), p-values, heterogeneity (I2 statistic), and heterogeneity p-values were estimated for the East-Asian meta-analyses under the fixed- and random-effect models using the inverse-variance method.