Table 1.

Amount of rhein and the corresponding experimental runs.

Run	Space Type	Ethanol Concentration (X1, % v/v)	Extraction Temperature (X2, °C)	Extraction Time (X3, min)	Amount of Rhein (Y, mg/g pulp) 1
1	Factorial	10	45	10	6.28 ± 1.53
2	Factorial	40	75	10	11.99 ± 1.33
3	Factorial	40	45	40	9.26 ± 1.50
4	Axial	0	60	25	9.14 ± 1.57
5	Center	25	60	25	10.33 ± 2.47
6	Center	25	60	25	11.33 ± 2.48
7	Center	25	60	25	10.38 ± 1.07
8	Axial	25	60	50	12.27 ± 0.24
9	Center	25	60	25	9.09 ± 3.55
10	Center	25	60	25	10.68 ± 1.13
11	Factorial	10	45	40	7.83 ± 0.39
12	Factorial	40	75	40	13.42 ± 1.57
13	Axial	50	60	25	10.41 ± 0.59
14	Factorial	10	75	10	9.75 ± 1.07
15	Factorial	40	45	10	8.62 ± 1.32
16	Factorial	10	75	40	15.69 ± 2.24
17	Axial	25	60	0	6.28 ± 0.50
18	Center	25	60	25	10.49 ± 1.79
19	Axial	25	35	25	5.88 ± 1.00
20	Axial	25	85	25	14.49 ± 2.12

¹ Data are expressed as means ± SD (n = 4).